Following an old ancient belief in different societies and cultures, having children has been a female duty. Accordingly, physicians considered infertility treatment as a mere gynecological problem. The various infertility treatment techniques were also originally directed and designed towards women’s complication. Long after the ART techniques were developed for treatment of women's infertility, they were made useful to cover men's problems too. Dissemination and development of laboratory techniques along with the innovation of the sperm intracytoplasmic injection (ICSI) method, has since 1993 resulted in enabling the spermatozoa, which were not able to fertilize spontaneously, to be used for fertilization. Since 1995, it was made possible to retrieve spermatozoa from epididimis and also from testis biopsy material for use in ICSI and in this way infertility treatment in azoespermic men with abstractive or non-abstractive etiology was materialized. It was thus necessary for a close cooperation between gynecologists, embryologists and andrologists. With specialization of infertility treatment and the necessity of involvement of after basic and clinical specialties, like endocrinology, genetics, immunology, biochemistry, infectious diseases, internal medicine, psychiatry, prenatology and neonatology, higher rate of success in treatment of multifactoral infertility complications have been achieved. The necessity of inter disciplinary cooperation among different specialties in ART treatment of infertility is further emphasized by the need in precise control of ovulation, prevention of hyper stimulation, treatment of immunologic factor variations in management of recurrent spontaneous abortion and ART failure, recognition of the role of STI and after infections in fertilization and fertility, analysis of effect of psycho-social consequences of infertility in different cultural backgrounds. Indeed, successful diagnosis and treatment of infertility seem impossible if these elements are disregarded it has now been revealed that this professional team work action is not provided unless by a comprehensive management. The most logical way is entire concurrent treatment in the form of presentation a package of infertility treatment to infertile couples by the professional specialists.